于明明 副教授

发布者:张栋发布时间:2018-05-14浏览次数:90

于明明,男,1985年生,博士,副教授。中国海洋大学“青年英才工程”计划资助获得者。20076月毕业于中国海洋大学药学专业,获得学士学位;20106月毕业于中国海洋大学药物化学专业,获得硕士学位;20141月毕业于中国海洋大学药物化学专业,获得博士学位。20118月至201212月在美国佛罗里达大学药学院Hartmut Derendorf教授实验室开展药物分析新方法和药物代谢动力学的研究;20131月至20138月在美国马里兰大学药学院从事药物分析新方法和药物临床药代动力学及安全性的研究。20143月至20159月在中国科学院上海药物研究所药物代谢中心从事博士后研究,主要研究内容为新药药物代谢动力学。201510月至201712月在美国马里兰大学从事博士后研究,主要研究内容为药物分析新方法和临床药代动力学。201712月经中国海洋大学青年英才工程人才引进到医药学院工作。在Clin. Pharmacokinet., J. Pharmaceut. Biomed., Bioanalysis., J. Chromatogr. B.等国际学术期刊发表论文10余篇。

联系方式:电话:(053282032064 E-mailyumingming@ouc.edu.cn

研究方向及内容:

  1. 药物分析新技术和新方法研究。

  2. 体内外药物代谢及其动力学分析。

  3. 群体PK/PD模型研究。

代表性论文:

[1] Mingming Yu, Zhiwei Gao, Xiaojian Dai, Hui Gong, Lianshan Zhang, Xiaoyan Chen, Da-Fang Zhong, Sherwin K.   B. Sy. Population pharmacokinetic and covariate analysis of apatinib, an oral tyrosine kinase inhibitor, in healthy volunteers and patients with solid tumors. Clinical Pharmacokinetics. 2017. 56: 65-76.

[2] Mingming Yu, Inas A. Abdallah, Soo Shin, Dana C. Hammell, Hazem E. Hassan, Audra L. Stinchcomb. LC-MS determination of fentanyl in human serum and application to a fentanyl transdermal delivery pharmacokinetic study. Bioanalysis. 2017, 9(20): 1551-1560.

[3] Mingming Yu, Yuanhong Wang, Fugang Ma, Weijie Yu, Tingfu Jiang, Zhihua Lv. Pharmacokinetics, tissue distribution and excretion study of fluorescein-labeled PS916 in rats. Current Pharmaceutical Biotechnology. 2017, 18(5): 391-399.

[4] Mingming Yu, Lilibeth A. Salvador, Sherwin K. B. Sy, Yufei Tang, Ravi Singh, Qi-Yin Chen, Yanxia Liu, Jiyong Hong, Hartmut Derendorf, Hendrik Luesch. Largazole Pharmacokinetics in Rats by LC/MS/MS. Marine Drugs. 2014, 12: 1623-1640.

[5] Mingming Yu, Hazem Hassam, Ahmed Ibrahima, Kenneth Bauer, Deanna L. Kelly, Jia Bei Wang. Determination of L-tetrahydropalmatine and cocaine in human plasma by UPLC and Its application in clinic studies. Journal of Chromatography B. 2014, 965: 39-44.

[6] Mingming Yu, Tingfu Jiang, Yuanhong Wang, Zhihua Lv. Identification and analysis of an impurity, which discovered in anti-adhesion carboxymethyl chitosan products, induced clinical adverse effect. Journal of Pharmaceutical and Biomedical Analysis. 2013, 85: 21-27.

[7] Mingming Yu, Zhihua Lv, Yuanhong Wang, Tingfu Jiang. Effects of Sulfate Chitosan Derivatives on Nonalcoholic Fatty Liver Disease. Journal of Ocean University of China. 2014, 13 (3): 531-537.

[8] 于明明,高志伟,陈笑艳,钟大放*.采用生理药动学模型预测抗肿瘤新药法米替尼在人体中的药动学. 药学学报. 2014, 49(12): 1684-1688.

[9] Zhiwei Gao, Yunting Zhu, Mingming Yu, Bin Zan, Jia Liu, Yifan Zhang, Xiaoyan Chen, Xuening Li, Dafang Zhong. Preclinical pharmacokinetics of TPN729MA, a novel PDE5 inhibitor, and prediction of its human pharmacokinetics using a PBPK model. Acta Pharmacologica Sinica. 2015, 36 (12): 1528-1536.

[10] Lizanne de Kock, Sherwin K. B. Sy, Bernd Rosenkranz, Andreas H Diacon, Kim Prescott, Heiner I Seifart, Mingming Yu, Hartmut Derendorf, Peter R Donald. Population Pharmacokinetics of Para-Aminosalicylic Acid in South African Tuberculosis-HIV Co-Infected Patients: an Interaction with Efavirenz. Antimicrobial Agents and Chemotherapy. 2014, 11; 58(10): 6242-6250. [11] Hazem E. Hassan, Deanna Kelly, Moshe Honick, Sagar Shukla, Ahmed Ibrahim, David A. Gorelick, Matthew Glassman, Robert P. McMahon, Heidi J. Wehring, Ann Marie Kearns, Stephanie Feldman, Mingming Yu, Ken Bauer, Jia Bei Wang. Pharmacokinetics and Safety Assessment of L-Tetrahydropalmatine in Cocaine Users: A Randomized, Double-blind, Placebo Controlled Study. Journal of Clinical Pharmacology. 2017, 57(2): 151-160.


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