王 成 副教授

发布者:张栋发布时间:2016-01-21浏览次数:84

 

 

王成博士, 副教授。主要从事生物医用纳米载体材料的构建、靶向给药系统的研究,主讲《药剂学》作为第一负责人主持完成国家自然科学基金、中国博士后科学基金、中国海洋大学青年教师基金等多项基金,以第三负责人参与完成国家科技重大专项—重大新药创制2项,并于20159月借调国家新药审评中心(CDE)挂职工作一年,兼任山东省一致性评价技术专家委员会药物制剂组专家。完成20多个新药申报,2016年所负责尼洛替尼胶囊获国家首仿临床批件。在Nat Med, J Biomed Nanotechnol, Oncotarget, Nanoscale, Curr Drug Metab, Int J Pharm等国际纳米载体及传输领域期刊上发表SCI论文16篇;申报中国发明专利9项,其中已获得授权4项。应邀为J Biomed Nanotechnol, Int J Pharm, Colloid and Surface B, J Nanosci Nanotechnol等国际杂志审稿十余篇次。

联系方式:0532-82031767  wangcheng@ouc.edu.cn

研究方向

(1)   靶向给药系统的研究

(2)   生物医用纳米载体材料的构建

(3)   应用药物制剂的研究与开发

代表性论文

1.Cheng Wang1*, Biao Liu2+, Xuelian Xu1, Bo Zhuang1, Hongxia Li1, Jiaqi Yin1, Mengyi Cong1, Wei Xu3,4* and Aiping Lu2*Toward Targeted Therapy in Chemotherapy-resistant Pancreatic Cancer with A Smart Triptolide Nanomedicine Oncotarget. 7(7). 8360-722016

2. Bo Zhuang, Liang Du, Hongxia Xu, Xuelian Xu,Cheng Wang*,Yingfang Fan, Mengyi Cong, Jiaqi Yin, Hongxia Li and Huashi Guan*. Self-assembled Micelle Loading Cabazitaxel for therapy of Lung Cancer. Int J Pharm. 499:146-155.2016.  

3. Yingfang Fan, Bo Zhuanga, Cheng Wang*, Xuelian Xu, Wei Xu, Zhihua Lv*. Pimecrolimus micelle exhibits excellent therapeutic effect for Keratoconjunctivitis Sicca. Colloid and Surface B. 140 1-10. 2016. 

4. Cheng Wang, Ying Shan, Jiuli Yang, Xuelian Xu, Bo Zhuang, Yingfang Fan and Wei Xu*. Inhibition of Cancer Angiogenesis Using Triptolide Nanoparticles .J Biomed Nanotechnol. 10:1-11. 805-815  2015.    

5.Chao Liang#, Baosheng Guo#, Heng Wu#, Ningsheng Shao, Defang Li, Jin Liu, Lei Dang, Cheng Wang, Hui Li, Shaohua Li, etc. Aptamer-functionalized lipid nanoparticles targeting osteoblasts as a novel RNAinterference-based bone anabolic strategy. Nat Med. 21(3):288-94,2015.  

6. Cheng Wang*, Biao Liu, Jun Lu, Ge Zhang and Aiping Lu*. Strategies for Combination of Aptamer and Targeted drug  delivery.  J Nanosci Nanotechnol. 14(1): 501-512,2014

7. Cheng Wang, Chaofeng Long, Chengshi Xie, Xiaoxin Chen, Lan Zhang, Bingyang Chu, Yujun Wang, Feng Luo, and Zhiyong Qian*  Two Novel Nanoscale Preparations of Micelle and Thermosensitive Hydrogel for Docetaxel to Treat Malignant Tumor. J Biomed Nanotechnol. 9(3): 357-366,2013                  

8. Cheng Wang,Jian Liang+, Xin Deng, Chaofeng Long, Chengshi Xie, Xiaoxin Chen, Lan Zhang, Qingfa Guo, Yingjing Wang, Yujun Wang, Feng Luo and Zhiyong Qian*. Systhesis, Characterization, and Application of Amino-Terminated Poly(ethylene glycol)-block-Poly(ε-caprolactone) Copolymer for Paclitaxel. J Nanosci Nanotechnol. 13(1): 68-76, 2013   

9. Cheng Wang, Jing Wang+, Tiezhu Chen, zhiqiang Luo, Xuemei Yang, Xiongfei Pan, Yunfeng Lin, zhiyong Qian* and Xiaoxiao Cai*.Absorption, Pharmacokinetics and Disposition of Biodegradable Nanoscale Preparations.Curr Drug Metab. 13(4): 429-439, 2012

10.Cheng Wang, YingJing Wang, YuJun Wang, Min Fan, Feng Luo, ZhiYong Qian*.Characterization, pharmacokinetics and disposition of novel nanoscale preparations of paclitaxel. Int J Pharm. 414(1-2): 251-259,2011


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