姜 帅 | 博士 | 教 授 | 博士生导师 | ||
科 室： | 药剂学实验室 | ||||
电子邮箱： | jiangshuai@ouc.edu.cn |
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研究方向： | 1. 纳米-生物相互作用：作用机制、生物效应与调控策略 2. 纳米粒子蛋白冠的分析检测技术开发及其生物效应研究 3. 酶纳米反应器的构建及其在纳米药物和合成生物学中的应用 | ||||
个人简介 |
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教授，博士生导师。2016年于中国科学院获博士学位，先后于德国马普高分子所进行博士联培和博士后研究并担任课题组长。2021年5月加入海大医药学院，主要从事纳米药物递送系统开发与纳米-生物界面作用的研究工作。主持国家自然科学基金、山东省优秀青年基金和中国海洋大学青年英才一层次基金等。发表SCI论文50余篇，其中以第一或通讯作者在Chem. Soc. Rev.、Acc. Chem. Res.、Angew. Chem.（5篇）、Adv. Mater.、Adv. Funct. Mater.、ACS Nano、Nano Lett. （2篇）等期刊发表论文30余篇，篇均影响因子10+，引用2000余次。 Google Scholar: https://scholar.google.de/citations?user=QU1qNosAAAAJ&hl=en Researchgate: https://www.researchgate.net/profile/Shuai-Jiang-10
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教育背景 |
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2013.12~2015.11 | 德国马普学会高分子研究所 | 高分子物理化学 | 博士联培 | ||
2011.09~2016.06 | 中国科学院大学 山西煤炭化学研究所 | 工业催化 | 硕博连读 | ||
2007.09~2011.06 | 烟台大学 | 化学工程与工艺 | 学士 | ||
工作经历 |
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2021.05~至今 | 中国海洋大学医药学院 | 教授 |
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2019.09~2021.04 | 德国马普学会高分子所 | 课题组长 |
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2016.08~2019.08 | 德国马普学会高分子所 | 博士后 |
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学术兼职 |
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担任期刊Frontiers in Materials客座编辑，期刊Polymers客座编辑和地区编委。 | |||||
研究进展 |
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纳米药物靶向递释系统是一种极具开发潜力的药物递送策略，其通过改变药物的代谢动力学和组织分布，提高对肿瘤组织的特异性作用并同时降低药物对正常组织的毒性，在肿瘤治疗等领域得到了广泛的重视和发展。针对现阶段抗肿瘤纳米药物临床转化率低的瓶颈问题，本课题组从高效、智能药物递送纳米载体和纳米反应器的开发和纳米-血液蛋白相互作用两方面开展研究。基于胶体化学和界面聚合，开发了纳米乳液原位包覆技术，针对特定药物的具体性质（如亲疏水性、生物活性、分子尺寸、释药需求等），发展出一系列特异性纳米胶囊药物递释载体和酶级联纳米反应器；结合材料表面修饰与表征、蛋白质组学和细胞、动物实验，建立了纳米材料-血液蛋白相互作用的研究方法学，揭示了纳米药物与血液蛋白吸附行为的作用机制、生物效应及调控方法，为全面、深入认识纳米药物的体内命运、推动抗肿瘤纳米药物的临床转化提供了重要研究基础。 | |||||
代表性成果 | |||||
代表性论文(*通讯作者；+共同一作) |
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28. F. Fu, S. Jiang,* et al. In situ characterization techniques of protein corona around nanomaterials. Chem. Soc. Rev.2024,53, 10827. 27. W. Han, S. Jiang,* et al. Self-Sustained Biophotocatalytic Nano-Organelle Reactors with Programmable DNA Switches for Combating Tumor Metastasis. Adv. Mater.2024. DOI: 10.1002/adma.202415030. 26. M. Prawatborisut, S. Jiang,*et al.Modulating Protein Corona and Materials-Cell Interactions with TemperatureResponsive Materials. Adv. Funct. Mater.2022, 32, 2106353. 25. R. Wang, S. Jiang,* et al. Liposomal Enzyme Nanoreactors based on Nanoconfinement for Efficient Anti-Tumor Therapy. Angew. Chem. 2023, 62, e202308761. 24. J. Gonçalves, S.Jiang,*et al. Confining the Sol-Gel Reaction at the Water/Oil Interface: Creating Compartmentalized Enzymatic Nano-Organelles for Artificial Cells. Angew. Chem. 2023, 62, e202216966. 23.S.Jiang,K. Landfester,* et al. Synthetic Silica Nano-Organelles for Regulation of Cascade Reactions in Multi-Compartmentalized Systems.Angew. Chem. 2021, 133, 2. 22. S. Jiang,K. Landfester,*et al.Synergistic Anticancer Therapy by Ovalbumin Encapsulation-Enabled Tandem ROS Generation.Angew. Chem.2020, 59, 2. 21. W. Huang,+N. Huber,+S. Jiang,+ K.Zhang,* et al. Covalent triazine framework nanoparticles via size-controllable confinement synthesis for enhanced visible light photoredox catalysis. Angew. Chem.2020, 59, 18368-18373. 20. S. Jiang,K. Landfester,*et al. One-Step Preparation of Fuel-Containing Anisotropic Nanocapsules with Stimuli-Regulated Propulsion. ACS Nano2019, 14, 498. 19. Y. Niu, S. Jiang,* et al. In Situ Measurement of Nanoparticle–Blood Protein Adsorption and Its Heterogeneity with Single-Nanoparticle Resolution via Dual Fluorescence Quantification. Nano Lett.2024, 24, 9202. 18. M. Li, S.Jiang,*et al. Brush Conformation of Polyethylene Glycol Determines the Stealth Effect of Nanocarriers in the Low Protein Adsorption Regime. Nano Lett. 2021, 21, 1591. 17. S. Jiang, D. Crespy,* et al. Nanocontainers in and onto Nanofibers. Acc. Chem. Res.2016, 49, 816. 16. M. Li,S. Jiang,*et al. Encapsulation of polyprodrugs enables an efficient and controlled release of dexamethasone. Nanoscale Horiz. 2021, 6, 791-800. 15. S.Jiang, K.Landfester,*et al. Visible light active nanofibrous membrane for antibacterial wound dressing. Nanoscale Horiz.2018,3, 439-446. 14. S.Jiang,D. Crespy,*et al. Efficient Nanofibrous Membranes for Antibacterial Wound Dressing and UV Protection. ACS Appl. Mater. Interfaces 2016,8, 29915-29922. 13. S.Jiang, K.Landfester,*et al. Controlling protein interactions in blood for effective liver immunosuppressive therapy by silica nanocapsules. Nanoscale2020,12, 2626-2637. 12. S.Jiang,D. Crespy,*et al. Tailoring nanoarchitectonics to control the release profile of payloads. Nanoscale2016,8, 11511-11517. 11. S. Jiang,Q. Li,*et al. Effect of surface silanization of carbon fiber on mechanical properties of carbon fiber reinforced polyurethane composites. Compos. Sci. Technol.2015,110, 87-94. 10. S. Jiang,Q. Li,*et al.Multiscale graphene oxide-carbon fiber reinforcements for advanced polyurethane composites. Compos. Part A2016,87, 1-9. 9. S.Jiang, K.Landfester,*et al. Versatile Preparation of Silica Nanocapsules for Biomedical Applications. Part. Part. Syst. Char.2020, 1900484. 8. S.Jiang,D. Crespy,*et al. Directed Assembly of Soft Anisotropic Nanoparticles by Colloid Electrospinning. Macromol. Rapid Commun.2016,37, 1598-1602. 7. S.Jiang,D. Crespy,* S.Mylon,* et al. The structure of fibers produced by colloid-electrospinning depends on the aggregation state of particles in the electrospinning feed. Polymer 2017,127, 101-105. 6. S.Jiang,D. Crespy,*et al. Nanofibrous photocatalysts from electrospun nanocapsules. Nanotechnology2017,28, 405601. 5. S.Jiang,D. Crespy,*et al. Control of the release of functional payloads from redox-responsive nanocapsules. RSC Adv. 2016,6, 104330-104337. 4. S.Jiang,D. Crespy,*et al. Dual-Responsive Multicompartment Nanofibers for Controlled Release of Payloads. RSC Adv. 2016,6, 43767-43770. 3. S.Jiang,Q. Li,*et al. Effect of carbon fiber-graphene oxide multiscale reinforcements on the thermos-mechanical properties of polyurethane elastomer. Polym. Composite2019, 40, E953-E961. 2. R.Thiramanas,+S.Jiang,+V. Mailander, et al. Silica Nanocapsules with Different Sizes and Physicochemical Properties as Suitable Nanocarriers for Uptake in T-cells. Int. J. Nanomedicine2020,15, 6069-6084. 1. Z. He,+S. Jiang,+Q. Li,*et al. Self-healing isocyanate microcapsules for efficient restoration of fracture damage of polyurethane and epoxy resins. J. Mater. Sci.2019, 54, 8262.
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项目课题 | |||||
1. 国家自然科学基金青年基金，纳米载体-血液蛋白相互作用在单颗粒水平的原位、定量表征，2023-2025，在研，主持。 2. 山东省优秀青年科学基金项目（海外），肿瘤靶向纳米药物研发与纳米-血液蛋白互作关系研究，2022-2025，在研，主持。 3. 中国海洋大学青年英才工程第一层次基金，纳米药物与纳米-生物界面研究，2021-2025，在研，主持。 4. 青岛海洋科学与技术国家实验室开放基金，2021-2025，在研，主持。 5. 胶类中药联合创新中心项目，2024-2026，在研，主持。 | |||||
