| 张 洋 | 博士 | 副教授 | 硕士生导师 |
科室： | 药理学平台 | |||
电子邮箱： | zhangyang@ouc.edu.cn |
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联系地址： | 山东省青岛市鱼山路5号中国海洋大学鱼山校区药物楼B205 | |||
研究方向： | 1.新型作用靶点导向的抗流感病毒药物设计与研发 2.病毒免疫学机制与疫苗及佐剂的应用研发 3.病毒与宿主糖链的相互作用机制研究 | |||
个人简介 | ||||
主要从事抗病毒药理学和病毒糖生物学的相关研究。主持国家自然科学基金委青年科学基金项目（C类）、山东省博士后创新项目，参与国家级/省级课题多项。近些年来在Journal of Medicinal Chemistry、Journal of Biological Chemistry、Journal of Medical Virology、Carbohydrate Polymers、Phytomedicine等国际主流期刊上发表论文近20篇，其中以第一作者或通讯作者（含共同）发表10余篇。 | ||||
工作经历 | ||||
2026.05~至今 | 中国海洋大学 医药学院 | 副教授 | ||
2023.08~2026.04 | 中国海洋大学医药学院 | 科研博士后（重点资助） | ||
学术兼职 | ||||
担任Antiviral Research、Marine Drugs、Vaccines等国际专业期刊审稿人。 | ||||
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研究进展 | ||||
1：抗流感病毒新靶点药物的挖掘与研究：
针对重大病原体-甲型流感病毒（IAV）展开其新靶点的研究。针对现有抗流感药物耐药性问题，研究转向高度
保守的病毒蛋白及宿主信号通路，从中药和海洋真菌中筛选获得多个结构多样的活性化合物，探索"病毒-宿主"
双重调控策略。
2：流感病毒糖疫苗及糖佐剂的研究：
成功构建小鼠体内流感病毒疫苗研究模型，明确中药多糖的免疫增强作用，为中药多糖的生物医药应用提供实证
支持，为开发新型、安全的生物佐剂提供候选物质。
3：病毒感染受体鉴定及研究：
成功构建HPV小鼠体内研究模型，并鉴定了HPV的进入辅助受体myosin-9，阐明细胞表面N糖链在HPV病毒进入
过程中的作用，为后续抗HPV药物以及展开病毒糖生物学研究奠定研究基础。
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代表性论文 | ||||||||||||||||
[1] Wenrui Gai#, Shuang Wu#, Bohan Li#, Yang Zhang#, Zihan Wang, Yueling Teng, Guangyuan Luo, Zhengjie Wang, Qi Wang, Wanting Jiao, Qian Che, Guojian Zhang, Tianjiao Zhu, Wei Wang*, Dehai Li*; Pocket-Based Generative Diffusion Model Accelerates Potent Influenza A Hemagglutinin Inhibitor Discovery, Journal of Medicinal Chemistry, 2026, 69(4), 4969–4983. [2] Xiaoyao Ma#, Yang Zhang#,*, LishanSuna#, Hongwei Zhao, Zihan Wang, Cui Hao*, Wei Wang*; Inhibition of influenza A virus infection by natural isoquinoline alkaloid neferine targeting virus nucleoprotein.Phytomedicine, 2026, 157873. [3] Mamadou Dioulde So#,Lishan Sun#, Hongwei Zhao, Zihan Wang, Yang Zhang*, Jinyu Wang, Wei Wang*; Inhibition of influenza A virus by salvianolic acid C targeting neuraminidase and phosphorylated-STAT3, Phytomedicine, 2025, 157715. [4] Wang Zihan#, Yang Zhang#*,Shangjie Xu, Lishan Sun, Hongwei Zhao, and Wei Wang*. Identifying a Marine-Derived Small-Molecule Nucleoprotein Inhibitor Against Influenza A Virus，Marine Drugs, 2025; 23(11):413. [5] Lishan Sun#, Yang Zhang#, Can Xu, Zhongqiu Xu, Xiayu Chen, Wei Wang, Cui Hao*,Carnosol inhibits influenza A virus by disrupting the viral envelope and interfering with Jak2/STAT3 signaling pathway, European Journal of Pharmacology, 2025, 177606. [6] Jinyu Wang, Yang Zhang, Lishan Sun, Zihan Wang, Cui Hao，Wei Wang*; Eukaryotic RNA binding protein hnRNPH1 suppresses influenza A virus replication through interaction with virus NS1 protein. Emerging microbes & infections, 2025，14(1), 2477645. [7] Yang Zhang#,Depeng Wang#, Daotong Tan, Anqi Zou, Zhe Wang, Yu Yang, Lishan Sun, Xiaoliang Lin, Ming Liang, Yi Yu, Xiaoxi He*, Guangli Yu*, Wei Wang*, Chao Cai*；Immune-enhancing activity of compound polysaccharide on the inactivated influenza vaccine，Carbohydrate Polymers,2024,336,122080. [8]Yang Zhang#; Wei Liu#; Fujie He; Yan-Jun Liu; Hao Jiang; Cui Hao; Wei Wang*; Myosin 9 and N-glycans jointly regulate human papillomavirus entry, Journal of Biological Chemistry, 2024, 300(2): 105660. [9]Yang Zhang#; Wei‐Feng Xu#; Yunjia Yu; Qun Zhang; Lianghao Huang; Cui Hao; Chang‐Lun Shao*; Wei Wang*; Inhibition of influenza A virus replication by a marine derived quinolone alkaloid targeting virus nucleoprotein, Journal of Medical Virology, 2023, 95(2): e28499. [10]Chen Ji; Wang Jinyu; Zhu Hongyu; Zhang Yang; Sun Jin; Wang Wei; Wei Congwen; Zhong Hui; Dong,Mingxin. Generation of a Live Attenuated Influenza A Vaccine Using Chemical-Triggered Intein，ACS Synthetic Biology，2023, 12, 6, 1686–1695. [11]Shixin Wang#, Yanan Luo#, Lianghao Huang, Shuyao Wang, Cui Hao, Lishan Sun, Yang Zhang, Wei Wang*, Chunxia Li*. The inhibition effects and mechanisms of sulfated chitooligosaccharides on influenza A virus in vitro and in vivo. Carbohydrate Polymers, 2022, 286:119316. [12]Jianghua Li#; Yang Zhang#; Chao Cai#*; Xiaozhi Rong; Meng Shao; Jiarui Li; Chendong Yang; Guangli Yu* ; Collaborative assembly of doxorubicin and galactosyldiblockglycopolymer s for targeted drug delivery of hepatocellular carcinoma, Biomaterials Science, 2020, 8(1): 189-200. [13] Wenmiao Li, Cuijing Xu, Cui Hao*, Yang Zhang, Zhaoqi Wang, Shuyao Wang, Wei Wang*. Inhibition of Herpes Simplex Virus by Myricetin through Targeting Viral gD Protein and Cellular EGFR/PI3K/Akt/mTOR Pathway. Antiviral Research, 2020, 177:104714. [14]Yunjia Yu#; Yang Zhang#; Shuyao Wang; Wei Liu; Cui Hao*; Wei Wang*; Inhibition effects of patchouli alcohol against influenza a virus through targeting cellular PI3K/Akt and ERK/MAPK signaling pathways, Virology journal, 2019, 16(1): 163.
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项目课题
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