邵长伦

发布者:胡斌发布时间:2023-09-04浏览次数:9330

K:\2019邵长伦.JPG

邵长伦

博士

教授

士生导师

科 室:

海洋天然药物研发

电子邮箱

shaochanglun@ouc.edu.cn

联系地址:

山东省青岛市鱼山路5号中国海洋大学医药学院266003

研究方向:

1海洋天然药物化学

2海洋药物先导化合物成药性研究

3海洋药用生物资源学

个人简介

  

  

  

  

针对国家开发重大创新药物的战略需求,依据海洋生物的化学防御策略,开展海洋天然药物先导化合物发现与优化研究。聚焦海洋天然药用生物新资源的高效发现与药物先导化合物可持续开发利用,针对海洋生物资源中天然药物化合物含量低微、结构复杂、制备困难等严重影响可持续开发及后续成药性评价等关键问题,系统构建了化学与功能导向技术体系,精准发掘了系列海洋药源化合物;应用理性化学合成策略,解决了多个重要先导化合物药源瓶颈问题;针对海洋蓝色药库开发计划,已发现2个候选药物进入较系统临床前研究阶段。

近年来,主持了国家自然科学基金(国家优青、山东省联合基金重点项目、面上项目、青年基金)、山东省自然科学基金(省杰青、青年基金)、崂山实验室鳌山人才、青年泰山学者和海洋局公益性专项等人才项目和基金;以通讯(共同)作者在Natural Product Reports, Journal of Medicinal Chemistry, Pharmacological Research, Journal of Medical Virology, European Journal of Medicinal Chemistry, Current Opinion in Chemical Biology, Communications Chemistry, Organic Letters, Marine Life Science & Technology, Journal of Organic Chemistry, Chemical Communications, Journal of Natural ProductsOrganic Chemistry Frontiers等国际知名期刊发表学术论文70余篇(含2ESI高被引论文和1篇封面文章)。论文被LANCET Infectious Diseases, Nature Reviews Chemistry, Nature Synthesis, Natural Product Reports, Journal of the American Chemical Society Angewandte Chemie-International Edition等国际顶尖期刊他引4600余次,论文H因子39。连续三年入选年度全球前2%顶尖科学家榜单(2020–2022, World's Top 2% Scientists以第一发明人获授权中国发明专利9件,美国发明专利3件。共同通讯作者撰写英文书籍《Studies in Natural Products Chemistry, Vol. 44》一章;共同主编普通高等学校十二五规划教材《海洋药物学》;作为编委成员参与编写《中华海洋本草》 (9)(管华诗, 王曙光主编,邵长伦等编委)。获山东省高等学校科学技术奖一等奖和青岛市自然科学奖二等奖。培养博士后出站4人,指导博士生18 人(其中7 人在读,11 人已毕业,含2名国际留学生),指导硕士生38 人(其中15 人在读,23 人已毕业)。


教育背景

  

  

  

  

2002.09~2007.07

中山大学

有机化学

博士

1998.09~2002.06

曲阜师范大学

化学教育

学士

工作经历

  

  

  

  

2014.01~今

中国海洋大学 医药学院

教授

博士生导师

2011.01~2013.12

中国海洋大学 医药学院

副教授

硕士生导师(2009年~今

2007.07~2010.12

中国海洋大学 医药学院

讲师

  

2011.11~2013.12

加州大学圣地亚哥分校Scripps海洋研究所(SIO, UCSD

访问学者

William H Gerwick课题组

学术兼职

  

  

  

  

国际期刊Marine Life Science & Technology海洋药物领域编辑(Section Editor2023.01~今)

中国药学会海洋药物专业委员会委员;中国海洋湖沼学会药物学分会理事;医学地质专业委员会第一届委员会委员;中国菌物学会菌物化学专业委员会委员;山东省青年科学家协会会员;青岛市高级专家协会会员;青岛市药学会中药与天然药物专业委员会青年委员会主任委员。

荣誉奖励

  

  

  

  

先后获得教育部新世纪优秀人才、国家自然科学基金优秀青年基金、山东省杰出青年基金、崂山实验室鳌山人才和泰山学者青年专家等人才项目资助。获山东省高等学校科学技术奖一等奖(位1)和青岛市自然科学奖二等奖(位1)。被评为山东省研究生创新成果一等奖指导教师和山东省“优秀硕士毕业论文”指导教师

承担课程

  

  

  

  

本科生课程:

《海洋药物学》(本科生专业特色课程);《药学与交叉学科创新研讨课》(本科生课程);

研究生课程:

《海洋药物化学》(研究生专业特色课程,山东省优质研究生课程,中国海洋大学研究生精品示范课,中国海洋大学研究生课程思政示范课程)。


承担项目

1. 国家自然科学基金优秀青年基金项目, 41322037, 海洋药用生物资源学, 2014/01至2016/12, 项目负责人。

2. 国家自然科学基金-山东省联合基金重点项目, U1706210, 海洋化学生态学指导下的药物先导化合物发现与优化, 2018/01至 2021/12, 项目负责人

3. 国家自然科学基金面上项目, 42376116, 基于分子网络技术和活性筛选体系的新颖环肽类天然产物高效发现与抗结核活性研究, 2024/01至 2027/12, 项目负责人

4. 国家自然科学基金面上项目, 41776141, 三株柳珊瑚来源真菌中氯代聚酮类海洋天然防污剂的发现与优化研究, 2018/01至 2021/12, 项目负责人

5. 国家自然科学基金面上项目, 41176121, 两种花柳珊瑚及其共附生微生物次级代谢产物与防污损活性研究, 2012/01至2015/12, 项目负责人

6. 国家自然科学基金青年基金项目, 30901879, 南海柳珊瑚Dichotella gemmacea及内生微生物化学防御物质及其抗肿瘤作用, 2010/01至2012/12,项目负责人

7. 山东省自然科学杰出青年基金项目, JQ201510, 海洋药用生物资源学, 2015/07 至 2018/07, 项目负责人

8. 山东省自然科学青年基金项目, ZR2011DQ019, 一种南海药用柳珊瑚共附生微生物代谢产物及其抗肿瘤作用研究, 2011/07至2014/07,项目负责人

9. 崂山实验室“鳌山人才”优秀青年学者项目, 2015ASTP-ES11, 海洋药用生物资源学, 2016/01 至 2018/12, 项目负责人

10. 国家海洋局海洋公益性行业科研专项经费项目, 201405038-4, 典型海洋环境药用生物资源多元化开发利用技术集成与示范,课题四:药用生物资源调研与《中华海洋本草》系列专注编撰, 2014/01至2017/12, 项目负责人

11. 新世纪优秀人才支持计划, NCET-11-0472, 海洋药用生物资源学, 2012/01至2014/12, 结题, 项目负责人。

12. 国家自然科学基金专项项目, 42142015, 战略研究类:海洋生态学与生物海洋学领域战略研, 2022/01至 2022/12, 结题, 学术骨干

13. 崂山实验室自由探索项目,8-01,海洋来源非酒精性脂肪性肝炎候选药物CHNQD-0803的靶点确定与机制研究2022/082024/07, 在研, 学术骨干

14.国家重点研发计划,2022YFC2601305,重点水域及航运中的重要入侵水生生物的防控技术研发及应用示范, 2022/112025/10, 在研, 学术骨干


代表性成果

代表性论文

  

  

  

  

(1) Yang Hai#, Zi-Mu Cai#, Peng-Jie Li, Mei-Yan Wei, Chang-Yun Wang, Yu-Cheng Gu*, Chang-Lun Shao*. Trends of antimalarial marine natural products: progresses, challenges and opportunities. Natural Product Reports, 2022, 39: 969990.

(2) Yao-Yao Jiang, Yang Gao, Jian-Yu Liu, Ying Xu, Mei-Yan Wei, Chang-Yun Wang, Yu-Cheng Gu, and Chang-Lun Shao*. Design and Characterization of a Natural Arf-GEFs Inhibitor Prodrug CHNQD-01255 with Potent Anti-Hepatocellular Carcinoma Efficacy In Vivo. Journal of Medicinal Chemistry, 2022, 65, 11970–11984.

(3) Feng-Wei Guo, Qun Zhang, Yu-Cheng Gu*, Chang-Lun Shao*. Sulfur-containing marine natural products as leads for drug discovery and development. Current Opinion in Chemical Biology, 2023, 75:102330.

(4) Yong Qu#, Tian-Yi Zhou#, Feng-Wei Guo#, Mei-Yan Wei, Guang-Ying Chen, Yu-Cheng Gu, Chang-Yun Wang, Chang-Lun Shao*. Analogues of natural products yaequinolones as potential inflammatory inhibitors: Design, synthesis and biological evaluation. European Journal of Medicinal Chemistry, 2023, 250, 115183.

(5) Yang Zhang#, Wei-Feng Xu#, Yunjia Yu#, Qun Zhang, Lianghao Huang, Cui Hao, Chang-Lun Shao*, Wei Wang*. Inhibition of influenza A virus replication by a marine derived quinolone alkaloid targeting virus nucleoprotein. Journal of Medical Virology, 2023, 95: e28499.

(6) Yi-Qian Han#, Qun Zhang#, Wei-Feng Xu*, Yang Hai, Rong Chao, Cui-Fang Wang, Xue-Mei Hou, Mei-Yan Wei, Yu-Cheng Gu, Chang-Yun Wang, Chang-Lun Shao*. Targeted isolation of antitubercular cycloheptapeptides and an unusual pyrroloindoline-containing new analog, asperpyrroindotide A, using LC-MS/MS-based molecular networking. Marine Life Science & Technology, 2023, 5, 8593.

(7) Feng-Wei Guo, Tian-Yi Zhou, Yong Qu, Mei-Yan Wei, Guang-Ying Chen, Yu-Cheng Gu, Chang-Yun Wang, Chang-Lun Shao*. Highly efficient and scalable total syntheses and stereochemical assignment of potent antiinflammatory pesimquinolones I and J. Organic Chemistry Frontiers, 2023, 10, 852.

(8) Feng-Wei Guo#, Xiao-Feng Mou#, Yong Qu, Mei-Yan Wei, Guang-Ying Chen, Chang-Yun Wang, Yu-Cheng Gu, Chang-Lun Shao*. Scalable total synthesis of (+)-aniduquinolone A and its acid-catalyzed rearrangement to aflaquinolones. Communications Chemistry, 2022, 5: 35.

(9) Li Xu#, Feng-Wei Guo#, Xue-Qing Zhang#, Tian-Yi Zhou, Chao-Jie Wang, Mei-Yan Wei, Yu-Cheng Gu, Chang-Yun Wang, Chang-Lun Shao*. Discovery, total syntheses and potent anti-inflammatory activity of pyrrolinone-fused benzoazepine alkaloids Asperazepanones A and B from Aspergillus candidus. Communications Chemistry, 2022, 5: 80.

(10) Yang Hai#, Jia-Jia Geng#, Peng-Jie Li#, Wei-Ping Ma, Cui-Fang Wang, Mei-Yan Wei*, Xue-Mei Hou, Guang-Ying Chen, Yu-Cheng Gu, Ming Liu*, Chang-Lun Shao*. Semisynthesis and biological evaluation of (+)-sclerotiorin derivatives as antitumor agents for the treatment of hepatocellular carcinoma. European Journal of Medicinal Chemistry, 2022, 232: 114166.

(11) Yao-Yao Jiang#, Shaochun Wu#, Yan-Wei Wu, Yang Gao, Daochen Chong, Changning Sun, Mei-Yan Wei, Yu-Cheng Gu, Chang-Lun Shao*, Yuchao Gu*. New brefeldin A-cinnamic acid ester derivatives as potential antitumor agents: Design, synthesis and biological evaluation. European Journal of Medicinal Chemistry, 2022, 240, 114598.

(12) Wei-Feng Xu#, Rong Chao#, Yang Hai, Yang-Yang Guo, Mei-Yan Wei, Chang-Yun Wang, and Chang-Lun Shao*. 17-Hydroxybrevianamide N and Its N1-Methyl Derivative, Quinazolinones from a Soft-Coral-Derived Aspergillus sp. Fungus: 13S Enantiomers as the True Natural Products. Journal of Natural Products, 2021, 84: 1353–1358.

(13) Rong Chao#, Xue-Mei Hou#, Wei-Feng Xu, Yang Hai, Mei-Yan Wei, Chang-Yun Wang, Yu-Cheng Gu, Chang-Lun Shao*. Targeted Isolation of Asperheptatides from a Coral-Derived Fungus Using LC-MS/MS-Based Molecular Networking and Antitubercular Activities of Modified Cinnamate Derivatives. Journal of Natural Products, 2021, 84: 11–19.

(14) Lorena Coronado#, Xue-Qing Zhang#, Doriana Dorta, Nerea Escala, Laura M. Pineda, Michelle G. Ng, Esther del Olmo, Chang-Yun Wang, Yu-Cheng Gu, Chang-Lun Shao*, and Carmenza Spadafora*. Semisynthesis, Antiplasmodial Activity, and Mechanism of Action Studies of Isocoumarin Derivatives. Journal of Natural Products, 2021, 84: 1434−1441.

(15) Chao-Jie Wang#, Xinxin Guo#, Rui-Qin Zhai, Changning Sun, Guokai Xiao, Jin Chen, Mei-Yan Wei, Chang-Lun Shao*, Yuchao Gu*. Discovery of penipanoid C-inspired 2-(3,4,5-trimethoxybenzoyl) quinazolin-4(3H)-one derivatives as potential anticancer agents by inhibiting cell proliferation and inducing apoptosis in hepatocellular carcinoma cells. European Journal of Medicinal Chemistry, 2021, 224:113671.

(16) Jin-Man Zhang#, Yao-Yao Jiang#, Qun-Fa Huang#, Xu-Xiu Lu, Guan-Hai Wang*, Chang-Lun Shao*, Ming Liu*, Brefeldin A delivery nanomicelles in hepatocellular carcinoma therapy: Characterization, cytotoxic evaluation in vitro, and antitumor efficiency in vivo. Pharmacological Research, 2021, 172:105800.

(17) Yang Hai, Mei-Yan Wei, Chang-Yun Wang, Yu-Cheng Gu, Chang-Lun Shao*. The intriguing chemistry and biology of sulfur containing natural products from marine microorganisms (1987–2020). Marine Life Science & Technology, 2021, 3, 488–518.

(18) Yun‑Fei Teng#, Li Xu#, Mei‑Yan Wei, Chang‑Yun Wang, Yu‑Cheng Gu, Chang‑Lun Shao*. Recent progresses in marine microbial‑derived antiviral natural products. Archives of Pharmacal Research, 2020, 43:1215–1229

(19) Xue-Mei Hou#, Ting-Mei Liang#, Zhi-Yong Guo, Chang-Yun Wang, Chang-Lun Shao*. Discovery, absolute assignments, and total synthesis of asperversiamides A–C and their potent activity against Mycobacterium marinum. Chemical Communications, 2019, 55, 1104–1107.

(20) Xue-Mei Hou, Yue-Ying Li, Yun-Wei Shi, Yao-Wei Fang, Rong Chao, Yu-Cheng Gu, Chang-Yun Wang*, Chang-Lun Shao*. Integrating Molecular Networking and 1H NMR To Target the Isolation of Chrysogeamides from a Library of Marine-Derived Penicillium Fungi. Journal of Organic Chemistry, 2019, 84, 1228–1237.

(21) Xue-Mei Hou, Chang-Yun Wang, William H. Gerwick*, Chang-Lun Shao*. Marine natural products as potential anti-tubercular agents. European Journal of Medicinal Chemistry, 2019, 165, 273–292.

(22) Lu Liu#, Yao-Yao Zheng#, Chang-Lun Shao*, Chang-Yun Wang*. Metabolites from marine invertebrates and their symbiotic microorganisms: molecular diversity discovery, mining, and application. Marine Life Science & Technology, 2019, 1: 6094.

(23)  Meng-Qi Zhang, Kai-Xia Xu, Ying Xue, Fei Cao, Lu-Jia Yang, Xue-Mei Hou, Chang-Yun Wang*, Chang-Lun Shao*. Sordarin Diterpene Glycosides with an Unusual 1,3-Dioxolan-4-one Ring from the Zoanthid-Derived Fungus Curvularia hawaiiensis TA26-15. Journal of Natural Products, 2019, 82, 2477−2482.

(24) Chang-Lun Shao, Xiao-Feng Mou, Fei Cao, Carmenza Spadafora, Evgenia Glukhov, Lena Gerwick, Chang-Yun Wang*, William H. Gerwick*. Bastimolide B, an Antimalarial 24-Membered Marine Macrolide Possessing a tert-Butyl Group. Journal of Natural Products, 2018, 81: 211–215.

(25) Xue-Qing Zhang, Xiao-Feng Mou, Ning Mao, Jie-Jie Hao, Ming Liu, Ji-Yong Zheng, Chang-Yun Wang, Yu-Cheng Gu, Chang-Lun Shao*. Design, semisynthesis, α-glucosidase inhibitory, cytotoxic, and antibacterial activities of p-terphenyl derivatives. European Journal of Medicinal Chemistry, 2018, 146: 232–244.

(26) Yan-Lai Jia#, Mei-Yan Wei#, Hai-Yan Chen, Fei-Fei Guan, Chang-Yun Wang*, Chang-Lun Shao*. (+)-and (−)-Pestaloxazine A, a Pair of Antiviral Enantiomeric Alkaloid Dimers with a Symmetric Spiro [oxazinane-piperazinedione] Skeleton from Pestalotiopsis sp. Organic Letters. 2015, 17: 4216–4219.

(27) Chang-Lun Shao, Roger G. Linington, Marcy J. Balunas, Argelis Centeno, Paul Boudreau, Chen Zhang, Niclas Engene, Carmenza Spadafora, Tina S. Mutka, Dennis E. Kyle, Lena Gerwick, Chang-Yun Wang, William H. Gerwick*. Bastimolide A, a Potent Antimalarial Polyhydroxy Macrolide from the Marine Cyanobacterium Okeania hirsuta. Journal of Organic Chemistry, 2015, 80: 7849–7855.

(28) Xue-Mei Hou, Ru-Fang Xu, Yu-Cheng Gu, Chang-Yun Wang*, Chang-Lun Shao*. Biological and Chemical Diversity of Coral-Derived Microorganisms. Current Medicinal Chemistry, 2015, 22: 37073762.

(29) Chang-Lun Shao, Ru-Fang Xu, Mei-Yan Wei, Zhigang She*, Chang-Yun Wang*. Structure and absolute configuration of fumiquinazoline L, an alkaloid from a gorgonian-derived Scopulariopsis sp. fungus. Journal of Natural Products, 2013, 76: 779−782.

(30) Kai-Lin Yang, Mei-Yan Wei, Chang-Lun Shao*, Xiu-Mei Fu, Zhi-Yong Guo, Ru-Fang Xu, Cai-Juan Zheng, Zhi-Gang She*, Yong-Cheng Lin, Chang-Yun Wang*. Antibacterial anthraquinone derivatives from a sea anemone-derived fungus Nigrospora sp. Journal of Natural Products, 2012, 75: 935–941.

(31) Chang-Lun Shao, Hui-Xian Wu, Chang-Yun Wang*, Qing-Ai Liu, Ying Xu, Mei-Yan Wei, Pei-Yuan Qian, Yu-Cheng Gu, Cai-Juan Zheng, Zhi-Gang She*, Yong-Cheng Lin. Potent antifouling resorcylic acid lactones from the gorgonian-derived fungus Cochliobolus lunatus. Journal of Natural Products, 2011, 74 (4): 629–633.

(32) Chang-Lun Shao, Chang-Yun Wang*, Yu-Cheng Gu, Mei-Yan Wei, Jia-Hui Pan, Dong-Sheng Deng, Zhi-Gang She*, Yong-Cheng Lin*. Penicinoline, a new pyrrolyl 4-quinolinone alkaloid with an unprecedented ring system from an endophytic fungus Penicillium sp., Bioorganic & Medicinal Chemistry Letters, 2010, 20 (11): 3284–3286.

(33) Changlun Shao, Changyun Wang, Meiyan Wei, Yucheng Gu, Xuekui Xia, Zhigang She*, Yongcheng Lin*. Structure elucidation of two new xanthone derivatives from the marine fungus Penicillium sp. (ZZF 32#) from the South China Sea. Magnetic Resonance in Chemistry, 2008, 46(11): 1066–1069.

(34) Changlun Shao, Zhigang She, Zhiyong Guo, Hong Peng, Xiaoling Cai, Shining Zhou, Yucheng Gu, Yongcheng Lin*. 1H and 13C NMR assignments for two anthraquinones and two xanthones from the mangrove fungus (ZSUH-36). Magnetic Resonance in Chemistry, 2007, 45(5): 434–438.



申请专利

中国授权专利

(1) 邵长伦,王长云胥汝芳. 一种生物碱类化合物及其制备方法与作为肿瘤细胞生长抑制剂的应用. 授权公告日: 2016.03.30. 授权公告: CN 103570744 B. 中国. 专利号: ZL201310130315.3.

(2) 邵长伦,王长云,魏美燕,胥汝芳,管菲菲. Sclerotiorin衍生物及其制备方法与作为抗甲型H1N1流感病毒剂的应用. 授权公告日: 2017.12.12. 授权公告号: CN 105218447 B. 中国. 专利号: ZL201510368592.7.

(3) 邵长伦,王长云,贾彦来,管菲菲,王翠芳,魏美燕. 一种生物碱二聚体及其制备方法与作为抗病毒剂的应用.

授权公告日: 2018.03.06. 授权公告号: CN 104876945 B. 中国. 专利号: ZL201510201548.7.

(4) 邵长伦,王长云,胥汝芳,管菲菲,魏美燕. 一种喹啉酮类化合物的制备方法与作为抗单纯疱疹型病毒剂的应用. 授权公告日: 2019.04.16. 授权公告: CN 106496203 B. 中国. 专利号: ZL201510918373.1.

(5) 邵长伦,王长云,魏美燕,王翠芳,管菲菲. Sclerotiorin衍生物及其制备方法与作为抗病毒剂的应用. 授权公告日: 2019.05.10. 授权公告号: CN 105219816 B. 中国. 专利号: ZL201510368647.4.

(6) 邵长伦,王长云,牟晓凤,胥汝芳. 一种生物碱类化合物及其制备方法与作为抗单纯疱疹Ⅰ型病毒剂的应用. 授权公告日: 2019.08.06. 授权公告: CN 106496202 B.中国. 专利号: ZL 201510918196.7.

美国授权专利

(1) 邵长伦,王长云,胥汝芳,管菲菲,魏美燕. Preparation and Anti-HSV-1 Application of Quinolinone Derivatives. 美国. 国际授权公告日: 2020.02.25. 专利号: US 10568877 B2. 国际申请号: PCT/CN2016/077663.

(2) 邵长伦,王长云,牟晓凤,胥汝芳. Alkaloids and Their Preparation and Application as anti-HSV-1 Agents. 美国. 国际授权公告日: 2020.05.05. 专利号: US 10639303 B2. 国际申请号: PCT/CN2016/077649.

(3) 邵长伦,王长云,牟晓凤,胥汝芳. Lactam Compound, Preparation Method and Use Thereof. 美国. 国际授权公告日: 2021.05.04. 专利号: US 10993938 B2. 国际申请号: PCT/CN2018/080727.



出版教材

  

  

  

  

1.海洋药物学》,科学出版社, 2011王长云 邵长伦主编,普通高等学校十二五规划教材