刘志清

刘志清

博士

教授

博士生导师

科 室：

海洋生物资源实验室

办公电话：

0532-82031503

电子邮箱：

liuzhiqing@ouc.edu.cn

联系地址：

山东省青岛市鱼山路5号中国海洋大学医药学院敏行馆B楼266003

研究方向：

1. 药物化学与化学生物学

2. 分子靶向的海洋药物先导物发现

3. 海洋药用生物资源

个人简介

教授、博士生导师。2019年9月以青年英才一层次引入中国海洋大学，2022年入选山东省泰山学者青年专家。围绕炎症、肿瘤等人类重大疾病，基于海洋天然产物开展了靶向药物设计合成、作用机制与先导物发现研究。已发表SCI论文30余篇，其中第一作者、通讯作者发表SCI文章20篇；申请国内外发明专利9项，获授权6项（美国授权5项、中国授权1项）；获得美国克罗恩病和炎性肠病基金会的Research Fellowship Award资助；近年来主持国家自然科学基金（面上）、中央高校基本科研业务费等项目；参编两部著作章节。

教育背景

2009.09-2014.06    

中国科学院上海药物研究所

药物化学

博士（导师：张翱 研究员）

2005.09-2009.06

山东师范大学

制药工程

学士

工作经历

2019.09至今

中国海洋大学

教授

2014.06-2019.08

美国得克萨斯大学医学分部

博士后

合作导师: Jia Zhou教授

学术兼职

Journal of Medicinal Chemistry、European Journal of Medicinal Chemistry等杂志审稿人。

承担课程

《海洋药物学》

代表性成果

代表性论文

1)      Lv, L. #;Maimaitiming, M. #; Huang, Y. #; Yang, J.; Chen, S.; Sun, Y.; Zhang, X.; Li, X.;Xue, C.; Wang, P.*; Wang, C.*;Liu, Z.*Discovery of quinazolin-4(3H)-one derivatives as novel AChE inhibitors with anti-inflammatory activities,European Journal of Medicinal Chemistry,2023,254:115346.

2)      Li, R.#; Zhou, Y.#; Zhang, X.; Yang, L.; Liu, J.; Wightman, S. M.; Lv, L.; Liu, Z.*; Wang, C.*; Zhao, C*. Identification of Marine Natural Product Pretrichodermamide B as a STAT3 Inhibitor for Efficient Anticancer Therapy. Mar. Life Sci. Technol., 2023,5, 94-101.

3)      Maimaitiming M. #;Lv L.#; Zhang X.; Xia S.; Li X.; Wang P.*;Liu Z.*; Wang C-Y*. Semi-Synthesis and Biological Evaluation of 25(R)-26-Acetoxy-3β,5α-Dihydroxycholest-6-One. Marine Drugs. 2023; 21(3):191.

4)      Li, H.#; Ouyang, S.#; Zhang, Y.; Peng, K.; Fang, W.; Liu, Z.*; Wang, C.*; Zhang, X.*; Wang, Y.* Structural Optimization of Imidazo[1, 2-a]pyridine Derivatives for theTreatment of Gastric Cancer via STAT3 Signaling Pathway. Eur. J. Med. Chem., 2022, 244:114858.

5)      Li, H.#; Maimaitiming, M.#; Zhou, Y.; Li, H.; Wang, P.; Liu, Y.; Schaberle, T. F.; Liu, Z.*; Wang, C.* Discovery of Marine Natural Products as Promising Antibiotics against Pseudomonas aeruginosa. Mar. Drugs, 2022, 20, 192.  

6)      Liu, Z.#; Li, Y.#; Chen, H.; Lai, H. T.; Wang, P.; Wu, S. Y.; Wold, E. A.; Leonard, P. G.; Joseph, S.; Hu, H.; Chiang, C. M.; Brasier, A. R.*; Tian, B.*; Zhou, J.* Discovery, X-ray Crystallography, and Anti-inflammatory Activity of Bromodomain-containing Protein 4 (BRD4) BD1 Inhibitors Targeting a Distinct New Binding Site. J. Med. Chem.,2022, 65,3, 2388-2408.   

7)      Liu, Z.*, Wang, P., Wold, E.A., Song, Q., Zhao, C., Wang, C.* and Zhou, J.* Small-Molecule Inhibitors Targeting the Canonical WNT Signaling Pathway for the Treatment of Cancer. J. Med. Chem.,2021, 64 (8), 4257-4288.

8)      Liu, Z.; Chen, H.; Wang, P.; Li, Y.; Wold, E. A.; Leonard, P. G.; Joseph, S.; Brasier, A. R.; Tian, B.; Zhou, J. Discovery of Orally Bioavailable Chromone Derivatives as Potent and Selective BRD4 Inhibitors: Scaffold Hopping, Optimization, and Pharmacological Evaluation. J. Med. Chem., 2020, 63, 5242-5256.

9)      Niu, Q.#; Liu, Z.#; Alamer, E.; Fan, X.; Chen, H.; Endsley, J.; Gelman, B. B.; Tian, B.; Kim, J. H.; Michael, N. L.; Robb, M. L.; Ananworanich, J.; Zhou, J.; Hu, H. Structure-guided drug design identifies a BRD4-selective small molecule that suppresses HIV. J. Clin. Invest. 2019, 129, 3361-3373. (#co-first author)

10)   Liu, Z.; Tian, B.; Chen, H.; Wang, P.; Brasier, A. R.; Zhou, J. Discovery of potent and selective BRD4 inhibitors capable of blocking TLR3-induced acute airway inflammation. Eur. J. Med. Chem. 2018, 151, 450-461.

11)   Tian, B.#; Liu, Z.#; Yang, J.; Sun, H.; Zhao, Y.; Wakamiya, M.; Chen, H.; Rytting, E.; Zhou, J.; Brasier, A. R. Selective Antagonists of the Bronchiolar Epithelial NF-κB-Bromodomain-Containing Protein 4 Pathway in Viral-Induced Airway Inflammation. Cell Rep. 2018, 23, 1138-1151. (#co-first author)

12)  Ali, S. R.#; Liu, Z.#; Nenov, M. N.; Folorunso, O.; Singh, A.; Scala, F.; Chen, H.; James, T. F.; Alshammari, M.; Panova-Elektronova, N. I.; White, M. A.; Zhou, J.; Laezza, F. Functional Modulation of Voltage-Gated Sodium Channels by a FGF14-Based Peptidomimetic. ACS Chem. Neurosci. 2018, 9, 976-987. (#co-first author)

13)  Liu, Z.; Wang, P.; Chen, H.; Wold, E. A.; Tian, B.; Brasier, A. R.; Zhou, J. Drug Discovery Targeting Bromodomain-Containing Protein 4. J. Med. Chem. 2017, 60, 4533-4558.

14)  Liu, Z.; Wild, C.; Ding, Y.; Ye, N.; Chen, H.; Wold, E. A.; Zhou, J. BH4 domain of Bcl-2 as a novel target for cancer therapy. Drug Discov. Today 2016, 21, 989-996.

15)  Liu, Z.; Ding, Y.; Ye, N.; Wild, C.; Chen, H.; Zhou, J. Direct Activation of Bax Protein for Cancer Therapy. Med. Res. Rev. 2016, 36, 313-341.

16)  Liu, Z.; Yue, X.; Song, Z.; Peng, X.; Guo, J.; Ji, Y.; Cheng, Z.; Ding, J.; Ai, J.; Geng, M.; Zhang, A. Design, synthesis and pharmacological evaluation of 2-(thiazol-2-amino)-4-arylaminopyrimidines as potent anaplastic lymphoma kinase (ALK) inhibitors. Eur. J. Med. Chem. 2014, 86, 438-448.

17)  Liu, Z.; Ai, J.; Peng, X.; Song, Z.; Wu, K.; Zhang, J.; Yao, Q.; Chen, Y.; Ji, Y.; Yang, Y.; Geng, M.; Zhang, A. Novel 2,4-Diarylanninopyrimidine Analogues (DAAPalogues) Showing Potent c-Met/ALK Multikinase Inhibitory Activities. ACS Med. Chem. Lett. 2014, 5, 304-308.

出版著作

1. Liu, Z.; Chen, H.; Wold, E. A.; Zhou, J. Small-Molecule Inhibitors of Protein–Protein Interactions. In Comprehensive Medicinal Chemistry III, Rotella, D.; Ward, S. E., Eds. Elsevier: Oxford, 2017; pp 329-353.

2. Liu, Z.; Chen, H.; Zhou, J. Apoptosis Regulator BAX. In Encyclopedia of Signaling Molecules, Choi, S., Ed. Springer New York: New York, NY, 2016; pp 1-6.

专利

1. Laezza, F., Zhou J., Liu, Z., Syed, A. Fine-tune modulators of neuronal excitability for neuropsychiatric disorders. US10889543B2. （2021.01.12授权）

2. Zhou, J., Brasier, A. R., Tian, B., Liu, Z., Chen, H., Rytting, E. Inhibitors of bromodomain-containing protein 4 (BRD4).US11117865B2. （2021.09.14授权）

3. Hu, H., Zhou, J., Liu, Z., Fan, X. EPAC1 activators as HIV latency reversal agents (LRAs). US10633363B2. （2020.04.28授权）

4. Zhou, J., Liu, Z., Ye, N., Mei F., Cheng, X. EPAC Antagonists. US11124489B2.（2021.09.21授权）

5. Hu, H.; Zhou, J.; Liu, Z. Novel small molecule BRD4 modulators for HIV epigenetic regulation. US 10975059B2.（2021.04.13授权）

6. 王长云，刘志清，杨金波，赵晨阳，王平原，周月，李锐，张心心，杨路佳。二酮哌嗪类天然产物及衍生物的应用、制备与所得衍生物，ZL202210076797.8（2023.01.11授权）

获奖

2009年山东省优秀毕业生

项目课题