| 王兆康 | 博士 | 教授 | 博士生导师 | |||||||
科 室： | 药剂学实验室 | ||||||||||
办公电话： | 电子邮箱： | dexterwong@ouc.edu.cn | |||||||||
联系地址： | 山东省青岛市鱼山路5号中国海洋大学医药学院药物楼B,邮编266003 | ||||||||||
研究方向： | 1. 纳米生物医学 2. 纳米复合水凝胶用于再生组织工程和生物医学应用 3.纳米药物递送 4. 生物传感器和成像 | ||||||||||
个人简介 |
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教授，博士生导师。中国海洋大学“青年英才工程”第一层次教授岗位，山东省“泰山学者”青年专家，山东省优秀青年（海外），国际先进材料协会的会士(IAAM Fellow)和终身会员。通讯作者在主要从事研发各种仿生纳米生物材料、光学技术的纳米探针，以及纳米药物递送系统用于组织工程与再生医学、癌症治疗/肿瘤生物学和免疫治疗等生物医学应用。近年来在国际权威学术期刊发表研究论文40余篇，其中以第一/通讯作者在Sci. Adv., Adv. Mater., Adv. Fun. Mater, ACS Nano, Nano Lett., Aggregate, Small, Theranostics, Biosens. Bioelectron., ACS Appl. Mater. Interfaces等国际权威期刊上发表论文 20余篇，其中2篇论文入选ESI高被引论文，以及一篇RSC著作。课题组主页：https://www.dynanolab.com/ | |||||||||||
教育背景 |
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2015~2019 | 香港中文大学 | 生物医学工程 | 博士 | ||||||||
2012~2015 | 香港中文大学 | 生物医学工程 | 学士 | ||||||||
工作经历 |
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2024~今 | 中国海洋大学医药学院 | 教授 |
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2020~2024 | 香港理工大学 | 助理教授(研究) |
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2019~2020 | 香港中文大学 | 博士后 |
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2018 | 斯坦福大学 | 访问学者 |
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2014 | 新加坡国立大学 | 研究助理 |
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学术兼职 |
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担任多个国际权威学术期刊（Adv. Mater.、J. Control Release、Nano Today、J. Nanobiotech.、Nano Lett.、Mil.Med.Res.、Adv.HealthcareMater.、ACS Sensors、Sci. Rep.等30多个期刊种类）的审稿人 国际先进材料协会的会士(IAAM Fellow)和终身会员 Frontiers in Bioengineering and Biotechnology的副编辑 Biomedical Engineering Communications的编委 皇家化学会会员(MRSC) 美国化学学会会员（MACS） 电气和电子工程师学会会员（MIEEE） 组织工程国际与再生医学学会（TERMIS）的会员 | |||||||||||
荣誉奖励 |
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IJMS杰出审稿人(2023年) 第二届全国博士后创新创业大赛海外赛道-优胜奖(2023年) 获选国际先进材料协会的会士，以表彰对“材料进步的全球卓越”的贡献(2023年) 国际先进材料学会科学家奖(2022年) 国际新科学发明研究奖（NESIN）最佳研究奖(2022年) 香港医疗保健设备行业协会研究生奖(2019年) 香港中文大学2018-19年度全球研究卓越奖学金计划(2018年) 第二届转化纳米医学国际学术研讨会(Elsevier出版社Biomaterials期刊主办)的最佳海报/快速发言奖(2017年) | |||||||||||
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研究进展 |
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王博士对于探索细胞与微环境之间的动态相互作用很感兴趣，这些相互作用可以对细胞内信号调控和重塑微环境的生物材料的物理化学特性起到重要的生物贡献。为了研究这种微观的现象，他和团队开发了各种仿生纳米生物材料和纳米复合水凝胶，通过机械力或生物化学途径调节相关信号通路，促进了特定的细胞培养和生长。为了实时观察细胞反应，王博士还开发了基于光学技术(如AIE)的多功能纳米探针，用于体内外检测。此外，这些多功能纳米探针可以实现药物递送用于疾病治疗，如癌症治疗和免疫治疗。
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代表性成果 | |||||||||||
代表性论文(+equal contribution; *corresponding author)： | |||||||||||
1. Chen, J., Ho, W.K.H., Yin, B., Zhang, Q., Li, C., Yan, J., Huang, Y., Hao, J., Yi, C., Zhang, Y., *Wong, S.H.D., *Yang, Mo, Magnetic-responsive upconversion luminescence resonance energy transfer (LRET) biosensor for ultrasensitivedetection of SARS-CoV-2 spike protein, Biosens. Bioelectron., 2023, 248, 115969 2. Yin, B., Zhang, Q., Yan, J., Huang, Y., Li, C., Chen, J., Wen, W., *Wong, S.H.D., *Yang, M., Nanomanipulation of Ligand Nanogeometry Modulates Integrin/Clathrin-Mediated Adhesion and Endocytosis of Stem Cells, Nano Lett. 2023, (19), 9160–9169 3. Zhang, Q., Yin B., Huang, Y., Gu, Y., Yan, J., Chen, J., Li, C., Zhang, Y., *Wong, S.H.D., *Yang, M., A dual "turn-on" biosensor based on AIE effect and FRET for in situ detection of miR- 125b biomarker in early Alzheimer's disease, Biosens. Bioelectron., 2023, 230, 115270 4. Yin, B., Ho, W. K. H., Xia, X. Y., Chan, C. K. W. Zhang, Q., Ng, Y. M., Lam, C. Y. K., Wang, J. F., *Yang, M., *Wong, S. H. D., A multilayered mesoporous gold nanoarchitecture for ultraeffective near-infrared light-controlled chemo/photothermal therapy for cancer guided by SERS imaging, Small 2023, 202206762 [Hot Topic: Mesoporous Materials (Small)] [Hot Topic: Surfaces and Interfaces (Advanced Materials Interfaces)] [Selected for Frontispiece in Small 6/2023] [ESI] 5. Yin, B., Wong, W.K., Ng, Y.M., Yang, M., *Leung, F.K.C., *Wong, S.H.D., Smart Design of Nanostructures for Boosting Tumor Immunogenicity in Cancer Immunotherapy, Pharmaceutics 2023, 15(5), 1427 6. +Wong, S.H.D., +Yin, B., Li, L., Yuan, W., Zhang, Q., Xie, X., Tan, Y., Wong, N, *Zhang, K., *Bian, L., Mechanical manipulation of cancer cell tumorigenicity via heat shock protein signaling, Sci. Adv.2023, 9(27), eadg9593 7. Wong, S.H.D., Deen, G.R., Bates, J.S., Maiti, C, Lam, C.Y.K., Pachauri, A., AlAnsari, R., Belsky, P., Yoon, J., Dodda, J.M., Smart skin-adhesive patches: From design to biomedical applications, Adv. Funct. Mater., 2023, 2213560 [Hot topic: Flexible Electronics (Advanced Intelligent Systems)] 8. Yin, B., Zhang, Q., Xia, X., Li, C., Ho, W.K.H., Yan, J., Huang, Y., Wu, H., Wang, P., Yi, C., Hao, J., Wang, J., Chen, H., *Wong, S.H.D., *Yang, M., A CRISPR-Cas12a integrated SERS nanoplatform with chimeric DNA/RNA hairpin guide for ultrasensitive nucleic acid detection, Theranostics, 2022, 12 (13), 5914-5930 9. +WONG, W. K., +Yin, B., Lam, C. Y. K., *Tan, Z., *Wong, S.H.D. The Interplay Between Epigenetic Regulation and CD8+ T cell Differentiation/Exhaustion for T cell Immunotherapy,Front. Cell Dev. Biol. 2022, 9:783227 10. Zhang, Q., Yin, B., Ma, L., Huang, Y., Shao, X., Li, C., Chu, Z., Hao, J., *Wong, S.H.D., *Yang, M., An AIEgen/graphene oxide nanocomposite (AIEgen@GO)-based two-stage “turn-on” nucleic acid biosensor for rapid detection of SARS-CoV-2 viral sequence. Aggregate, 2022, 3, e195 11. +Yin, B., +Ho, W.K.H., Zhang, Q., Li, C., Huang, Y., Yan, J., Yang, H., Hao, J., *Wong, S.H.D., *Yang, M., Magnetic-Responsive Surface-Enhanced Raman Scattering Platform with Tunable Hot Spot for Ultrasensitive Virus Nucleic Acid Detection. ACS Appl. Mater. Interface. 2022, 14, 3, 4714–4724 [Featured in PolyU Vibrant@FENG - Issue 3, Jul/Aug. 2022] 12. Yin, B., Ni, J., Witherel, C. E., Yang, M., *Burdick, J. A., *Wen, C., *Wong, S.H.D., Harnessing Tissue-derived Extracellular Vesicles for Osteoarthritis Theranostics. Theranostics, 2021, 12(1): 207-231 [ESI] 13. +Zhang, J., +Wong, S. H. D., Wu, X., Lei, H., Qin, M., Shi, P., *Wang, W., *Bian, L., *Cao, Y. Engineering Photo-responsive Ligand Tethers for Mechanical Regulation of Stem Cells. Adv. Mater. 2021, 33(48): 2105765 [Feature in PolyU Vibrant@FENG - Issue 3, Jul/Aug. 2022] 14. Wong, S. H. D., Xu X., Chen X., Xin Y., Xu L., Lai C. H. N., Oh J., Wong W. K., Wang X., Han S., You W., Shuai X., Wong N., Tan Y., Li D., Bian L. Manipulation of the nanoscale presentation of integrin ligand produces cancer cells with enhanced stemness and robust tumorigenicity. Nano Lett. 2021, 21, 7, 3225–3236 [Featured in PolyU Vibrant@FENG - Issue 2, Dec. 2021] 15. +Lam, C. Y. K., +Zhang, Q., Yin, B., Huang, Y., Wang, H., *Yang M., *Wong, S.H.D., Recent Advances in Two-dimensional Transition Metal Dichalcogenide Nanocomposites Biosensors for Virus Detection Before and During COVID-19 outbreak J. Compos. Sci. 2021, 5(7), 190 16. +WONG, W. K., +Yin, B., Rakhmatullina, A., *Zhou, J., *Wong, S. H. D., Engineering Advanced Dynamic Biomaterials to Optimize Adoptive T-cell Immunotherapy. Eng. Regen. 2021, 2, 70–81 17. Wong, S.H.D., Wong, W.K.R. Lai, N.C.H. Oh, J. Li, Z. Chen, X. Yuan, W. Bian, L., Soft polymeric matrix as a macroscopic cage for magnetically modulating reversible nanoscale ligand presentation. Nano Lett., 2020, 20, 5, 3207–3216 18. +Kang, H., +Wong, S.H.D. Pan, Q., Li, G. Bian, L., Anisotropic ligand nanogeometry modulates the adhesion and polarization state of macrophages, Nano Lett. 2019, 19(3): 1963–1975 19. +Wong, S.H.D., +Yin, B., Lin S., Yang, B., Li, R., Feng, F., Yang, H., Zhang, L., Yang, Z., Li, G., Choi, C. H., Bian, L., Anisotropic nanoscale presentation of cell adhesion ligand enhances the recruitment of diverse integrins in adhesion structures and mechanosensing-dependent differentiation of stem cells, Adv. Funct. Mater., 2019, 29 (8): 1806822 20. +Kang, H., +Wong, S.H.D., Yan, X., Jung, H.J., King, S.K., Lin, Si., Wei, K., Li, G., Dravid, V., Bian, L., Remote control of multi-Modal nanoscale ligand oscillations regulates stem cell adhesion and differentiation, ACS Nano, 2017, 11(10): 9636–9649 21. Wong, S.H.D., Li, J., Yan, X., Wang, B., Zhang, L., Bian, L. Magnetically tuning tether mobility of integrin ligand regulates adhesion, spreading, and differentiation of stem cells, Nano Lett., 2017, 17 (3): 1685–1695 | |||||||||||
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